Long-chain dicarboxylic acids play a critical role in inducing peroxisomal β-oxidation and hepatic triacylglycerol accumulation

Recent studies provide evidence that peroxisomal β-oxidation negatively regulates mitochondrial fatty acid oxidation, and induction of causes hepatic lipid accumulation. However, whether there exists a triggering mechanism inducing is not clear. Long-chain dicarboxylic acids are the product mono subjected to ω-oxidation, both ω-oxidation induced under ketogenic conditions, indicating might be crosstalk between. Here, we revealed administration long-chain strongly induces steatosis in mice through metabolites acetyl-CoA hydrogen peroxide. Under upregulation resulted increased generation β-oxidation, which accumulation droplets animals. Inhibition reduced formation significantly lowered improved steatosis. Our results suggest endogenous act as molecules triacylglycerol deposition. Targeting an effective pathway treating liver related metabolic diseases regulating β-oxidation.